Exceptional third-time single-lung transplantation in a cystic fibrosis patient with previous pneumonectomy: a case report

Françoise Le Pimpec-Barthes, Giuseppe Mangiameli, Ciprian Pricopi, Alex Arame, Anne Hernigou, Romain Guillemain, Véronique Boussaud

Abstract

We report for the first time in literature an exceptional case of a third-time lung transplantations (LTx) done on a single lung because of previous pneumonectomy in a cystic fibrosis 22-year-old female. Several hypotheses were advocate to explain the need of persistent continuous noninvasive ventilation occurred after left pneumectomy. Finally, chronic lung allograft dysfunction (CLAD) associated with near- diaphragmatic palsy secondary to lung distension was the retained diagnosis. Twenty-three months after third-time single lung retransplantation she is still alive, in good condition, with a Forced Expiratory Volume in 1 second (FEV1) measured at 47%, justifying the accepted risk and the technical difficulties of an exceptional procedure.